期刊
JOURNAL OF CHROMATOGRAPHY A
卷 1228, 期 -, 页码 250-262出版社
ELSEVIER
DOI: 10.1016/j.chroma.2011.07.019
关键词
Monolith; Polymerization; Chromatography; HPLC; Isocratic mode; Small molecules
资金
- Office of Science, Office of Basic Energy Sciences, U.S. Department of Energy [DE-AC02-05CH11231]
- National Institute Institutes of Health [GM-48364, EB-006133]
The separations of small molecules using columns containing porous polymer monoliths invented two decades ago went a long way from the very modest beginnings to the current capillary columns with efficiencies approaching those featured by their silica-based counterparts. This review article presents a variety of techniques that have been used to form capillary formats of monolithic columns with enhanced separation performance in isocratic elutions. The following text first describes the traditional approaches used for the preparation of efficient monoliths comprising variations in polymerization conditions including temperature as well as composition of monomers and porogenic solvents. Encouraging results of these experiments fueled research of completely new preparation methods such as polymerization to an incomplete conversion, use of single crosslinker, hypercrosslinking, and incorporation of carbon nanotubes that are described in the second part of the text. (C) 2011 Elsevier B.V. All rights reserved.
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