期刊
JOURNAL OF CHROMATOGRAPHY A
卷 1219, 期 -, 页码 66-74出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.chroma.2011.11.026
关键词
Orthogonal array design; Membrane-protected micro-solid phase extraction; Sulfonamides; Food analysis
资金
- Natural Science Foundation of China [81173018, 21105033, 21177099]
- Natural Science Fund of Hubei Province [2010CDB03205]
- Huazhong University of Science and Technology [0124514009]
- Fundamental Research Funds for the Central Universities [01-09-514944]
In the present study, a simple and sensitive extraction method based on polypropylene membrane-protected micro-solid phase extraction (MP-mu-SPE) has been developed for analysis of sulfonamides in food samples. Poly (methacrylic acid-ethylene glycol dimethacrylate) (p-MAA-EDMA) was synthesized using orthogonal array experimental design, optimized with three factors at four levels and evaluated on yield, hydrophobic and cation-exchange properties. The optimized p-MAA-EDMA was then employed as the sorbent in the MP-mu-SPE for extraction of sulfonamides from milk and chicken muscle samples, followed by high performance liquid chromatographic analysis with ultraviolet detection. Under optimized extraction conditions, good linearities (0.010-1.0 mu g mL(-1) with r(2) > 0.9900), low limits of detection (0.38-0.62 ng mL(-1)), and acceptable intra-day (2.7-13.7%) and inter-day (6.7-15.2%) relative standard deviations were obtained. It was demonstrated to be an effective approach to handle semi-solid/solid samples with good resistance to interference from dirty samples. (C) 2011 Elsevier B.V. All rights reserved.
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