期刊
JOURNAL OF CHROMATOGRAPHY A
卷 1248, 期 -, 页码 130-138出版社
ELSEVIER
DOI: 10.1016/j.chroma.2012.05.088
关键词
Exact mass database; High resolution Orbitrap mass spectrometry; Pesticide; Veterinary drug; Generic extraction; Honey
资金
- Spanish Ministry of Economy and Competitiveness (MINECO)
- FEDER [AGL2010-21370]
- MINECO [AGL2010-21370]
- Juan de la Cierva Program (MINECO-European Social Fund, ESF)
- Ramon y Cajal Program (MINECO-ESF)
A database has been created for the simultaneous analysis of more than 350 pesticides and veterinary drugs (including antibiotics) using ultra-high performance liquid chromatography coupled to high resolution Orbitrap mass spectrometry (UHPLC-Orbitrap-MS). This is a comprehensive exact mass database built using the Exactive-Orbitrap analyzer. The developed database includes exact masses of the target ions and retention time data, and allows the automatic search of the included compounds. Generic chromatographic and MS conditions have been applied. The presented database is suitable for qualitative analysis, and it was also evaluated for quantitative purposes in routine analysis, after the optimization and validation of a generic extraction method in honey samples. Adequate recovery and precision values for most of the studied analytes were obtained and the limits of detection (LOD) ranged from 1 to 50 mu g kg(-1). For pesticides, LODs were always lower than the MRLs established by European Union in honey, except for a few compounds. This method was applied to the analysis of 26 real honey samples and some pesticides (azoxystrobin, coumaphos, dimethoate and thiacloprid) were detected in 4 samples. Azoxystrobin and coumaphos were determined in two different samples (organic honey) at 1.5 mu g kg(-1) and 5.1 mu g kg(-1). Veterinary drugs were not detected in the analyzed samples. (c) 2012 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据