期刊
JOURNAL OF CHROMATOGRAPHY A
卷 1231, 期 -, 页码 52-58出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.chroma.2012.02.006
关键词
Endocrine disrupting compounds; Heart-cutting; 2D-chromatography; Atmospheric pressure photoionization
资金
- Grant Agency of the Czech Republic [GACR P503/10/0975]
The multi-heart-cutting two-dimensional liquid chromatography-tandem mass spectrometry method using atmospheric pressure photoionization has been developed and successfully validated for the determination of nine endocrine disrupting compounds in river water. The method is based on the use of two different reverse-phase columns connected through a six-port two-position switching valve equipped with a 200 mu l loop. An orthogonal separation was achieved by proper selection of stationary phases, mobile phases, and the use of a gradient elution in both dimensions. The method shows excellent performance in terms of accuracy (86.2-111.1%), precision (intra-batch: 6.7-11.2%, inter-batch: 7.2-13.5%), and sensitivity (1.2-7.1 ng l(-1)). Twenty real samples collected from the Loucka and the Svratka rivers were analyzed, the studied compounds were found in all Svratka samples (9.7-11.2 ng l(-1) for beta-estradiol, 7.6-9.3 ng l(-1) for estrone, and 24.6-38.7 ng l(-1) for bisphenol A). (c) 2012 Elsevier B.V. All rights reserved.
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