期刊
NEUROPSYCHOPHARMACOLOGY
卷 40, 期 10, 页码 2287-2297出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/npp.2015.118
关键词
-
资金
- One Mind
- Department of Veterans Affairs (DVA) [1I01CX000748-01A1, I01CX000120-01]
- Mid-Atlantic Mental Illness, Research, and Education Center
- NIH (NIMH)
- HHMI
- Burroughs Wellcome Fund
- Brain and Behavior Fund
- ProMedica Klarman Family Foundation ANGI Welcome Trust Strategic Awards Committee (London)
- US Department of Veterans Affairs
- NIH
- Thome Memorial Foundation
- American Foundation for Suicide Prevention
- Schering Plough Pharmaceuticals
- NARSAD [YI 19233]
- Conquer Cancer Foundation
- NIH [MH085806, MH088609, DK100392, MD009064]
The development of posttraumatic stress disorder (PTSD) is influenced by genetic factors. Although there have been some replicated candidates, the identification of risk variants for PTSD has lagged behind genetic research of other psychiatric disorders such as schizophrenia, autism, and bipolar disorder. Psychiatric genetics has moved beyond examination of specific candidate genes in favor of the genome-wide association study (GWAS) strategy of very large numbers of samples, which allows for the discovery of previously unsuspected genes and molecular pathways. The successes of genetic studies of schizophrenia and bipolar disorder have been aided by the formation of a large-scale GWAS consortium: the Psychiatric Genomics Consortium (PGC). In contrast, only a handful of GWAS of PTSD have appeared in the literature to date. Here we describe the formation of a group dedicated to large-scale study of PTSD genetics: the PGC-PTSD. The PGC-PTSD faces challenges related to the contingency on trauma exposure and the large degree of ancestral genetic diversity within and across participating studies. Using the PGC analysis pipeline supplemented by analyses tailored to address these challenges, we anticipate that our first large-scale GWAS of PTSD will comprise over 10 000 cases and 30 000 trauma-exposed controls. Following in the footsteps of our PGC forerunners, this collaboration-of a scope that is unprecedented in the field of traumatic stress-will lead the search for replicable genetic associations and new insights into the biological underpinnings of PTSD.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据