期刊
NEUROPSYCHOPHARMACOLOGY
卷 40, 期 7, 页码 1631-1639出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/npp.2015.7
关键词
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资金
- NARSAD
- National Institute of Mental Health [R01 MH076995, R01 MH060004]
- NSLIJ Research Institute General Clinical Research Center [M01 RR018535]
- Advanced Center for Intervention and Services Research [P30 MH090590]
- Center for Intervention Development and Applied Research [P50 MH080173]
- Bristol-Meyers Squibb
- Janssen
- Otsuka
- Janssen Pharmaceutica
Little is known regarding the neuropsychological significance of resting state functional magnetic resonance imaging (rs-fMRI) activity early in the course of psychosis. Moreover, no studies have used different approaches for analysis of rs-fMRI activity and examined gray matter thickness in the same cohort. In this study, 41 patients experiencing a first-episode of psychosis (including N = 17 who were antipsychotic drug-naive at the time of scanning) and 41 individually age-and sex-matched healthy volunteers completed rs-fMRI and structural MRI exams and neuropsychological assessments. We computed correlation matrices for 266 regions-of-interest across the brain to assess global connectivity. In addition, independent component analysis (ICA) was used to assess group differences in the expression of rs-fMRI activity within 20 predefined publicly available templates. Patients demonstrated lower overall rs-fMRI global connectivity compared with healthy volunteers without associated group differences in gray matter thickness assessed within the same regions-of-interest used in this analysis. Similarly, ICA revealed worse rs-fMRI expression scores across all 20 networks in patients compared with healthy volunteers, with posthoc analyses revealing significant (p<0.05; corrected) abnormalities within the caudate nucleus and planum temporale. Worse processing speed correlated significantly with overall lower global connectivity using the region-of-interest approach and lower expression scores within the planum temporale using ICA. Our findings implicate dysfunction in rs-fMRI activity in first-episode psychosis prior to extensive antipsychotic treatment using different analytic approaches (in the absence of concomitant gray matter structural differences) that predict processing speed.
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