期刊
JOURNAL OF CHROMATOGRAPHY A
卷 1218, 期 2, 页码 334-342出版社
ELSEVIER
DOI: 10.1016/j.chroma.2010.11.036
关键词
Analyte protectants; Matrix-induced enhancement effect; Pesticides multi-residue analysis; Gas chromatography-mass spectrometry (GC-MS); Chinese herbs
资金
- Major Drug Discovery science and technology special program Technical standards platform on detection of harmful residues in TCM [2009ZX09308-006]
The phenomenon known as matrix-induced enhancement effect is not only observed in the analysis of pesticides in food, but also in Chinese herbs. Several approaches have been proposed to overcome the matrix-induced effect, but each method has serious limitations. Compared with standard calibration methods, the procedure with adding analyte protectants offers a more convenient and effective route to solve the problem. In the current study, we have analyzed 195 types of pesticides in Chinese herbs by gas chromatography-mass spectrometry (GC-MS), and the compounds that are susceptible to matrix effect were picked up and confirmed. In addition, several analyte protectants were evaluated and the most effective combination was determined. D-Ribonic acid-gamma-lactone (2 mg/ml) and D-sorbitol (1 mg/ml) were shown to be the best analyte protectants for the analysis of most pesticides. (C) 2010 Elsevier B.V. All rights reserved.
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