期刊
JOURNAL OF CHROMATOGRAPHY A
卷 1217, 期 8, 页码 1219-1226出版社
ELSEVIER
DOI: 10.1016/j.chroma.2009.12.035
关键词
Solid-phase extraction; Core-shell microspheres; Magnetite microspheres; Endocrine disrupting chemicals; Estrogen mimics
资金
- Hong Kong Special Administrative Region. China [AoE/P-04/2004]
- Shenzhen-HongKong Innovative Circle of Shenzhen City
A new Fe3O4/poly(divinylbenzene-co-methacrylicacid)core-shell magnetite microspheric material have been successfully developed as magnetic-mediated solid-phase extraction micro-particle sorbent ill dispersion mode (MM-SPE-MP) for the determination of selected estrogenic endocrine disrupting chemicals (EDCs).namely estrone(E1),17 beta-estradiol(E2),estriol(E3).17 alpha-ethynylestradiol(EE2)and bisphenol-A (BPA), in natural water, via quantification by HPLC tandem mass spectrometry The magnetite Fe3O4 core of this MM-SPE-MP sorbent was fabricated by a solvothermal approach and the thin layer of amphipolar poly((divinylbenzene-co-methacrylic acid))(pDVB-MAA)coating was established via suspension polymerization The resultant core-shell MM-SPE-MP sorbent material was characterized by electron microscopy.. X-ray diffraction and Fourier-transformed infiared spectroscopy. Particle size distribution of the core-shell microspheres was within the range 300-700 nm in diameter and the thickness of the pDVB-MAA coating was ca 10 nm This magnetite microspheric material can be easily dispersed In aqueous Samples and retrieved by the application of external magnetic field via a small piece of permanent magnet The MM-SPE-MP process for the selected estrogenic EDCs involved the dispersion of the core-shell macrospheric sorbent in water samples with sonication. followed by magnetic aided retrieval of the sorbent and solvent (methanol) desorption of extracted EDCs for LC-MS/MS analysis Partition equilibrium for all the selected EDCs onto this MM-SPE-MP sot bent was achieved within 15 mitt Recoveries of the EDCs were in ranges of 56-111% Analytes with smaller K-ow value showed relatively lower recovery (and relatively longer equilibration time for partitioning) Method detection limits achieved were found to be 1-36 pg ml(-1) (n=3). while the repeatability was 6-34%(p<005, n=3) This work demonstrates the usefulness of MM-SPE-MP in the rapid and highly sensitive monitoring of trace organic contaminants in natural waters (C) 2009 EIsevier B.V All rights reserved
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