期刊
JOURNAL OF CHROMATOGRAPHY A
卷 1217, 期 6, 页码 858-880出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.chroma.2009.11.068
关键词
HPLC; Basic compounds; Stationary phases; Reversed-phase; HILIC
This review considers some of the difficulties encountered with the analysis of ionised bases using reversed-phase chromatography, such as detrimental interaction with column silanol groups, and overloading which both lead to poor peak shapes. Methods of overcoming these problems in reversed-phase (RP) separations, by judicious selection of the column and mobile phase conditions, are discussed Hydrophilic interaction chromatography is considered as an alternative method for the separation of some basic compounds. (C) 2009 Elsevier B.V. All rights reserved.
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