期刊
JOURNAL OF CHROMATOGRAPHY A
卷 1216, 期 46, 页码 8200-8205出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.chroma.2009.04.008
关键词
Nitroxinil; Oxyclozanide; Rafoxanide; Closantel; LC-MS/MS; Method validation
资金
- UK Department for Environment, Food and Rural Affairs [VM02146]
This paper describes an analytical method for four phenolic and salicylanilide anthelmintics authorised for use within the EU (nitroxinil, oxyclozanide, rafoxanide and closantel) in bovine kidney, and the extension of this procedure to include a number of related compounds: ioxynil, niclosamide, salicylanide and 3-trifluoromethyl-4-nitrophenol (TFM). The method comprises a solvent extraction with 1% acetic acid in acetone and clean-up using a mixed-mode anion-exchange solid phase extraction column. Determination is by reversed phase LC-MS/MS. The method was validated to the latest EU requirements (Commission Decision 2002/657/EC) using both spiked and incurred tissues and was subject to second laboratory evaluation. Crown Copyright (C) 2009 Published by Elsevier B.V. All rights reserved.
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