期刊
JOURNAL OF CHROMATOGRAPHY A
卷 1216, 期 14, 页码 2913-2922出版社
ELSEVIER
DOI: 10.1016/j.chroma.2008.10.042
关键词
Comprehensive two-dimensional gas chromatography; Time of flight mass spectrometry; Doping control; Anabolic agents; 3 '-Hydroxystanozolol
Doping control screening based on the enhanced resolution of comprehensive two-dimensional (2D) gas chromatography hyphenated to time of flight mass spectrometer was investigated. The identification of anabolic agents (clenbuterol, norandrosterone, epimetendiol, two nnethyltestosterone metabolites and 3'-hydroxystanozolol) contained in a spiked urine sample (2 ng/ml) was demonstrated. Special emphasis was given to 3'-hydroxystanozolol, mainly considering the difficulty in its detection. In contrast to conventional GC-MS approaches that must use single-ion monitoring, the GC x GC-TOFMS method enabled the identification of that metabolite through the deconvolution of the full mass spectrum and also resolved the co-eluted peaks of 3'-hydroxystanozolol and an endogenous component. (C) 2008 Elsevier B.V. All rights reserved.
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