期刊
JOURNAL OF CHROMATOGRAPHY A
卷 1216, 期 14, 页码 2749-2756出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.chroma.2008.10.125
关键词
Human breath; Exhaled air; Cancer biomarkers; Metabolite profiles; Lung cancer profiles; Hydrocarbons; SPME-GC-(TOF)-MS; Multivariate analysis; Pattern recognition
The gas chromatographic profiles of exhaled air from lung cancer patients have been investigated. The breath from healthy volunteers, smokers and non-smokers, and lung cancer patients without treatment and under radio and/or chemotherapy, was collected using Tedlar bags. Different profiles for healthy people and cancer patients could be recognized by multivariate analysis and significant diagnostic compounds could be established. Target compounds showed to be linear and branched hydrocarbons between C-14 and C-24. Solid phase microextraction (SPME) coupled to gas chromatography mass spectrometry CC-(TOF)-MS was used. The method showed good precision (RSD below 26%) and limit of detection ranged from 0.04 to 8.0 ppb. These findings show a high potential for establishment of laboratorial screening methods. Validation studies in a larger number of patients are being done. (C) 2008 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据