期刊
JOURNAL OF CHROMATOGRAPHY A
卷 1216, 期 34, 页码 6210-6217出版社
ELSEVIER
DOI: 10.1016/j.chroma.2009.06.085
关键词
Two-dimensional liquid chromatography; Multidimensional chromatography; Parallel columns
资金
- US Department of Energy [DE-FG05-88-ER-13869]
- University of Tennessee
- Oak Ridge National Laboratory
The theoretical advantages and drawbacks of using a multiple-, parallel column approach in on-line multi-dimensional liquid chromatography systems were investigated. Much time or peak capacity can be gained with the use of multiple parallel columns at the second-dimension while the aggregate time of separation increases only by the increment of the gradient time of the second-dimension. Multidimensional chromatographic systems are now used to perform many tasks ranging from routine, fast analyses to specialized, arduous separations. In this work,we focus on the advantages of a Multiple, parallel columns approach to on-line multidimensional liquid chromatography systems. Calculations of the achievable peak capacities were made as functions of the number of columns operated in parallel. Increasing the number of second-dimension columns from one to two or three causes the largest increase in peak capacity with only a slight increase of aggregate time. We also present some practical aspects to consider when attempting multidimensional separations with multiple columns operated in parallel. (c) 2009 Elsevier B.V. All rights reserved.
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