期刊
JOURNAL OF CHROMATOGRAPHY A
卷 1216, 期 11, 页码 2195-2203出版社
ELSEVIER
DOI: 10.1016/j.chroma.2008.11.030
关键词
Panax ginseng; HPLC-FTICR-MS; Ginsenoside; Intestinal bacteria; Metabolism; TNO gastro-intestinal model (TIM); Acidic hydrolysis; Metabolite profiling
资金
- Royal Netherlands Academy of Science-Chinese Academy of Sciences [05CDP010]
- Ministry of Science and Technology of China [2007DFA31060]
A high-performance liquid chromatography-high resolution Fourier transform ion cyclotron resonance mass spectrometry (HPLC-FTICR-MS) method was developed to investigate the metabolism of ginsenosides in in vitro models of the gastro-intestinal tract. The metabolites were identified by high-resolution tandem mass spectrometry. Degradation and bioconversion routes of the different ginsenosides at acidic (gastric) conditions and in the presence of intestinal microbiota were elaborated. Besides hydrolysis (deglycosylation) also hydration reactions Occurred at acidic conditions. The results illustrate the value of metabolite profiling by HPLC-FTICR-MS for understanding of the mechanisms in bioavailability of herbal drugs and their metabolites. (C) 2008 Elsevier B.V. All rights reserved.
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