期刊
JOURNAL OF CHROMATOGRAPHY A
卷 1208, 期 1-2, 页码 242-245出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.chroma.2008.08.121
关键词
L-Phenylalanine; Chiral stationary phases; Peptide length; Secondary structure; Liquid chromatography
Three new chiral stationary phases with different lengths of L-phenylalanine peptide were prepared by solid-phase synthesis with tert-butoxycarbonyl (Boc)-L-phenylalanine on silica. The effect of phenylalanine peptide length on enantioselectivity was studied. The best separation of R/S-warfarin was achieved by the chiral stationary phase with intermediate peptide length. These stationary phases were found to exist mainly in alpha-helical conformation by using FT-IR spectra. The end-capping reagents for the N-terminus of the peptide were also evaluated. (c) 2008 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据