期刊
JOURNAL OF CHROMATOGRAPHY A
卷 1204, 期 2, 页码 204-209出版社
ELSEVIER
DOI: 10.1016/j.chroma.2008.04.013
关键词
ionic liquids; chiral separation; capillary electrophoresis; pharmaceutical products; sodium cholate; 1-S-octyl-beta-D-thioglucopyranoside
A chiral ionic liquid (IL), S-[3-(chloro-2-hydroxypropyl)trimethylammonium] [bis((trifluoromethyl) sulfonyl)amide] (S-[CHTA](+)[Tf2N](-)), which can be easily and readily synthesized in a one-step process from commercially available reagents. can be successfully used both as co-electrolyte and as a chiral selector for CE. A variety of pharmaceutical products including atenolol, propranolol, warfarin, indoprofen, ketoprofen. ibuprofen and flurbiprofen, can be successfully and baseline separated with the use of this IL as electrolyte. Interestingly, while S-[CHTA](+)[Tf2N](-) can also serve as a chiral selector, enantioseparation cannot be successfully achieved with S-[CHTA](+)[Tf2N](-) as the only chiral selector. In the case of ibuprofen, a second chiral selector, namely a chiral anion (sodium cholate), is needed for the chiral separation. For furbiprofen. in addition to S-[CHTA](+)[Tf2N](-) and sodium cholate, a third and neutral chiral selector, 1-S-octyl-beta-D-thioglucopyranoside(OTG), is also needed. Due to the fact that the chirality of this chiral IL resides on the cation (i.e., -[CHTA](+)), and that needed additional chiral selector(s) are either chiral anion (i.e., cholate) or chiral neutral compound (OTG), the results obtained seem to suggest that additional chiral selector(s) are needed to provide the three-point interactions needed for chiral separations. (c) 2008 Elsevier B.V. All rights reserved.
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