期刊
JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY
卷 56, 期 7, 页码 774-781出版社
WILEY
DOI: 10.1111/jcpp.12342
关键词
Pragmatic language; social communication; autism spectrum disorder; social (pragmatic) communication disorder; siblings; high-risk
资金
- NIMH [R01 MH068398, U54 MH068172, P50 HD055784]
BackgroundWe evaluated early pragmatic language skills in preschool-age siblings of children with autism spectrum disorder (ASD), and examined correspondence between pragmatic language impairments and general language difficulties, autism symptomatology, and clinical outcomes. MethodsParticipants were younger siblings of children with ASD (high-risk, n=188) or typical development (low-risk, n=119) who were part of a prospective study of infants at risk for ASD; siblings without ASD outcomes were included in analyses. Pragmatic language skills were measured via the Language Use Inventory (LUI). ResultsAt 36months, the high-risk group had significantly lower parent-rated pragmatic language scores than the low-risk group. When defining pragmatic language impairment (PLI) as scores below the 10(th) percentile on the LUI, 35% of the high-risk group was identified with PLI versus 10% of the low-risk group. Children with PLI had higher rates of general language impairment (16%), defined as scores below the 10(th) percentile on the Receptive or Expressive Language subscales of the Mullen Scales of Early Learning, relative to those without PLI (3%), but most did not evidence general language impairments. Children with PLI had significantly higher ADOS scores than those without PLI and had higher rates of clinician-rated atypical clinical best estimate outcomes (49%) relative to those without PLI (15%). ConclusionsPragmatic language problems are present in some siblings of children with ASD as early as 36months of age. As the new DSM-5 diagnosis of Social (Pragmatic) Communication Disorder (SCD) is thought to occur more frequently in family members of individuals with ASD, it is possible that some of these siblings will meet criteria for SCD as they get older. Close monitoring of early pragmatic language development in young children at familial risk for ASD is warranted.
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