期刊
JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY
卷 56, 期 6, 页码 702-710出版社
WILEY
DOI: 10.1111/jcpp.12329
关键词
Autism spectrum disorders; comorbidity; genetics; twins
资金
- Swedish Council for Working Life
- Research Council of the Swedish National Alcohol Monopoly
- Soderstrom-Konigska Foundation
- ALF
- Swedish Research Council
BackgroundEvidence from twin and molecular genetic studies is accumulating that Autism Spectrum Disorder (ASD) shares substantial etiological factors with other disorders. This is mirrored in clinical practice where ASD without coexisting disorders is rare. The present study aims to examine the range of coexisting disorders in ASD in a genetically informative cohort. MethodsParents of all Swedish 9-year-old twins born between 1992 and 2001 (n=19,130) underwent a telephone interview designed to screen for child psychiatric disorders, including ASD. To ensure full coverage of child psychiatric disorders, data were also retrieved from population-based health registers. We investigated the coexistence of eight psychiatric disorders known to coexist with ASDs in probands and their co-twins. ResultsHalf of the individuals with ASDs (50.3%) had four or more coexisting disorders and only 4% did not have any concomitant disorder. The healthy co-twin' in ASD discordant monozygotic twin pairs was very often (79% of boys and 50% of girls) affected by at least one non-ASD disorder. The corresponding figures for ASD discordant dizygotic twin pairs were significantly lower (46% of males and 30% of females). ConclusionsDetailed phenotypic descriptions including symptoms of problems associated with a wide range of child psychiatric disorders may aid in unraveling the genetic architecture of ASD and should guide the development of intervention strategies addressing each problem type specifically.
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