期刊
JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY
卷 51, 期 4, 页码 432-458出版社
WILEY
DOI: 10.1111/j.1469-7610.2010.02214.x
关键词
Autism spectrum disorders; early markers; genetics; brain development; siblings; perinatal development; diagnosis
资金
- Israeli Science Foundation (ISF) [18.0-540/03]
- United States-Israel Binational Science Foundation (BSF) [2007-209]
- Autism Speaks (USA)
- Autism Speaks (UK)
- Medical Research Council
Autism is one of the most heritable neurodevelopmental conditions and has an early onset, with symptoms being required to be present in the first 3 years of life in order to meet criteria for the 'core' disorder in the classification systems. As such, the focus on identifying a prodrome over the past 20 years has been on pre-clinical signs or indicators that will be present very early in life, certainly in infancy. A number of novel lines of investigation have been used to this end, including retrospective coding of home videos, prospective population screening and 'high risk' sibling studies; as well as the investigation of pre- and peri-natal, brain developmental and other biological factors. While no single prodromal sign is expected to be present in all cases, a picture is emerging of indicative prodromal signs in infancy and initial studies are being undertaken to attempt to ameliorate early presentation and even 'prevent' emergence of the full syndrome.
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