期刊
JOURNAL OF CHILD NEUROLOGY
卷 30, 期 6, 页码 749-756出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/0883073814543303
关键词
PET; PANDAS; Tourette syndrome; brain inflammation; basal ganglia
资金
- Mental Illness Research Association (MIRA)
- Baiardi Family Foundation, Inc.
We applied PET scanning with C-11-[R]-PK11195 (PK) to evaluate neuroinflammatory changes in basal ganglia and thalamus in children with clinically diagnosed pediatric autoimmune neuropsychiatric disorders associated with streptococcal infection (PANDAS) and Tourette syndrome. Seventeen children with PANDAS (mean age: 11.4 +/- 2.6 years; 13 males), 12 with Tourette syndrome (mean age: 11.0 +/- 3.0 years; 10 males), and 15 normal adults (mean age: 28.7 +/- 7.9 years; 8 males) underwent dynamic PK PET imaging and binding potential, a measure of ligand-TSPO receptor (expressed by activated microglia) binding, was calculated for basal ganglia and thalamus. Binding potential values, suggesting underlying activated microglia-mediated neuroinflammation, were found to be increased in bilateral caudate and bilateral lentiform nucleus in the PANDAS group and in bilateral caudate nuclei only in the Tourette syndrome group, compared to control group. These differences in the pattern and extent of neuroinflammation also signify a possible difference in pathophysiological etiology between PANDAS and Tourette syndrome patients.
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