期刊
NEUROPSYCHOLOGIA
卷 77, 期 -, 页码 90-96出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuropsychologia.2015.08.006
关键词
Psychodermatology; Delusional infestation; Neuroimaging; Rubber hand illusion; Interoception
资金
- Sackler Centre for Consciousness Science, University of Sussex, UK
- Medical Research Council [MR/K002643/1] Funding Source: researchfish
- National Institute for Health Research [ACF-2009-27-003] Funding Source: researchfish
- MRC [MR/K002643/1] Funding Source: UKRI
Some patients experience skin sensations of infestation and contamination that are elusive to proximate dermatological explanation. We undertook a functional magnetic resonance imaging study of the brain to demonstrate, for the first time, that central processing of infestation-relevant stimuli is altered in patients with such abnormal skin sensations. We show differences in neural activity within amygdala, insula, middle temporal lobe and frontal cortices. Patients also demonstrated altered measures of self-representation, with poorer sensitivity to internal bodily (interoceptive) signals and greater susceptibility to take on an illusion of body ownership: the rubber hand illusion. Together, these findings highlight a potential model for the maintenance of abnormal skin sensations, encompassing heightened threat processing within amygdala, increased salience of skin representations within insula and compromised prefrontal capacity for self-regulation and appraisal. (C) 2015 Elsevier Ltd. All rights reserved.
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