期刊
JOURNAL OF CHILD NEUROLOGY
卷 28, 期 8, 页码 1027-1033出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/0883073813487598
关键词
ketogenic diet; mechanism of action; glucose; ATP-sensitive K channel; mammalian target of rapamycin; vesicular glutamate transporters; Seizure; epilepsy
资金
- Johns Hopkins University School of Medicine
- [K08NS070931]
The ketogenic diet and its newer variants are clinically useful in treating epilepsy. They can also have antiepileptogenic properties and can eventually have a role in treating other neurologic and nonneurologic conditions. Despite being nearly a century old, identifying the molecular underpinnings of the ketogenic diet has been challenging. However, recent studies provide experimental evidence for 4 distinct mechanisms that could contribute to the antiseizure and other beneficial effects of these diets. These mechanisms include carbohydrate reduction, activation of adenosine triphosphate (ATP)-sensitive potassium channels by mitochondrial metabolism, inhibition of the mammalian target of rapamycin pathway, and inhibition of glutamatergic excitatory synaptic transmission.
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