期刊
JOURNAL OF CHILD NEUROLOGY
卷 29, 期 4, 页码 534-537出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/0883073812473645
关键词
dopamine; dystonia; Quality Of Upper Extremity Skills Test
资金
- ILAN, The Israeli Foundation for Handicapped Children
Although levodopa is the main treatment for dystonia, its role in cerebral palsy has not been assessed. We hypothesized that levodopa will improve upper limb function in individuals with cerebral palsy. Nine participants (age 16.8 +/- 5.6 years) with quadriplegic cerebral palsy and upper limb dystonia were enrolled in this randomized, double-blind, placebo-controlled, crossover study. Function was assessed before and after 2 weeks of treatment of levodopa and placebo using box-and-blocks, 9-hole pegs, dynamometer recordings, and Quality of Upper Extremity Skills Test. No benefits for upper limb functional performance were found following levodopa (6.65 +/- 1.66 mg/kg/d) treatment compared to placebo. No side effects were reported.
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