期刊
JOURNAL OF CHILD NEUROLOGY
卷 27, 期 5, 页码 641-644出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/0883073811423974
关键词
gross motor; fine motor; neurofibromatosis type 1; NF1; inherited cancer syndrome; brain tumor
It is well documented that children with neurofibromatosis type 1 are at high risk for a variety of cognitive and learning deficits. The current study investigated the use of a developmental screening tool, the Parents' Evaluation of Developmental Status: Developmental Milestones, as an accurate, reliable, and efficient indicator of developmental delays. Sixty-eight percent of children with neurofibromatosis type 1 were found to have a developmental delay in at least 1 of the 8 areas tested by the Parents' Evaluation of Developmental Status: Developmental Milestones. Significant developmental abnormalities were found in the areas of fine motor (35%), gross motor (52%), and math/premath (31%). A positive association was found between the presence of a previously diagnosed optic glioma and math/premath delays (chi(2) = 0.0022) and between male sex and fine motor delays (chi(2) = 0.0325). The Parents' Evaluation of Developmental Status: Developmental Milestones assessment demonstrates the high presence of developmental delays in children with neurofibromatosis type 1 and the need for aggressive and early screening.
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