期刊
JOURNAL OF CHILD NEUROLOGY
卷 26, 期 7, 页码 891-894出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/0883073810393962
关键词
manganese; neurotoxicity; parkinsonism; dystonia
A previously healthy 5-year-old girl presented with pica, emotional lability, and marked gait abnormalities. She had concurrent severe iron deficiency and polycythemia. Her magnetic resonance imaging (MRI) scan showed increased signal in the basal ganglia on T1-weighted images consistent with manganese neurotoxicity. Manganism was subsequently confirmed as her blood manganese levels were extremely elevated. Chelation therapy resulted in improvement in her mobility but she continues to have significant gait impairment. An epidemiological investigation identified well water as the potential source of manganese exposure for our patient, but to date, we have been unable to identify the nature of her neurotoxic susceptibility.
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