期刊
JOURNAL OF CHILD NEUROLOGY
卷 27, 期 1, 页码 11-21出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/0883073811420495
关键词
children; transverse myelitis; multiple sclerosis; MRI; outcome measures; neuromyelitis optica
资金
- Multiple Sclerosis Scientific Research Foundation
- Multiple Sclerosis Society of Canada
- Canadian Institutes of Health Research
The authors collected demographic, clinical, and neuroimaging data prospectively on 38 children with transverse myelitis. One child died during the illness. The female:male ratio was 1.2:1 for children under age 10 years and 2.6:1 over age 10 years. Twenty-eight (74%) reported a prodromal event. Twenty-two patients (58%) had longitudinally extensive transverse myelitis, 9 (24%) had focal lesions, and 5 (13%) had both. Twenty of 33 with brain imaging (61%) had brain lesions; 7 fulfilled McDonald criteria for dissemination in space. Seven of 22 (36%) tested had cerebrospinal fluid oligoclonal banding, 6 of whom had brain lesions. Serum neuromyelitis optica IgG antibodies were absent in all 20 of the children for whom this test was available. At follow-up (mean 3.2 +/- 2.0 years), 16% are wheelchair-dependent, 22% have persisting bladder dysfunction, and 13% have been diagnosed with multiple sclerosis.
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