期刊
JOURNAL OF CHILD NEUROLOGY
卷 24, 期 9, 页码 1147-1157出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/0883073809338327
关键词
inflammation; leukodystrophies; myelin; neuroinflammation; peroxisomal disorders; periventricular leukomalacia
资金
- NINDS NIH HHS [R01 NS037766, R01 NS034741, NS-40810, 5R13NS040925-09, R01 NS040810, NS-22576, R37 NS022576, NS-37766, R13 NS040925, NS-34741, R01 NS022576, R01 NS022576-26] Funding Source: Medline
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R37NS022576, R01NS022576, R01NS034741, R13NS040925, R01NS040810, R01NS037766] Funding Source: NIH RePORTER
The peroxisome, an ubiquitous subcellular organelle, plays an important function in Cellular metabolism, and its importance for human health is underscored by the identification of fatal disorders caused by genetic abnormalities. Recent findings indicate that peroxisomal dysfunction is not only restricted to inherited peroxisomal diseases but also to disease processes associated with generation of inflammatory mediators that downregulate cellular peroxisomal homeostasis. Evidence indicates that leukodystrophies (i.e. X-linked adrenoleukodystrophy, globoid cell leukodystrophy, and periventricular leukomalacia) may share common denominators in the development and progression of the inflammatory process and thus in the dysfunctions of peroxisomes. Dysfunctions of peroxisomes may therefore contribute in part to white matter disease and to the mental and physical disabilities that develop in patients affected by these diseases.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据