期刊
JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY
卷 22, 期 1, 页码 56-64出版社
MARY ANN LIEBERT, INC
DOI: 10.1089/cap.2011.0054
关键词
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资金
- Stanley Medical Research Foundation
- American Academy of Child and Adolescent Psychiatry
- Mayo Clinic
- Neuronetics, Inc.
- Neuronetics
- Stanley Medical Research Institute
- National Alliance for Schizophrenia and Depression (NARSAD)
- National Institute of Mental Health (NIMH) [5 K23 MH070897-02]
- National Institute of Neurological Disorders and Stroke
- National Institute on Aging
- Cyberonics
- St. Jude Advanced Neuromodulation Systems, Inc.
- Magstim
- Brainsway
- Biobehavioral Diagnostics, Inc.
- Eli Lilly
- Forest Laboratories
- GlaxoSmithKline
- Somerset
- Department of Defense [03/2011-12/2013 DM090122, 09/30/10-06/30/14 1 U01MH092221-01]
- NIH/NCRR [5 UL1 RR024982-02]
- Defense Academy for Credibility Assessment
- Cephos Corp.
Objective: To examine changes in motor cortical excitability in adolescent subjects receiving 30 sessions of high-frequency prefrontal repetitive transcranial magnetic stimulation (rTMS). Methods: Eight adolescents with treatment-resistant major depressive disorder (MDD) enrolled in an open augmentation trial of 10 Hz rTMS. Resting motor thresholds were obtained by the visualization of movement method with a maximum likelihood threshold hunting computer algorithm at baseline and after every five sessions of rTMS. Motor threshold was recorded as the percentage of total machine output at each measurement. Results: Motor threshold data from baseline, weeks 2, 4, and 5 were included in a mixed model repeated measure analysis to examine a change in least square mean effect over time. The omnibus effect did not reach statistical significance (F = 1.25, p = 0.32). However, multiple comparisons from the overall model demonstrated a decrease in the least square mean motor threshold. The mean contrast from baseline to week 5 approached significance (p = 0.07). Moreover, a post-hoc analysis with a Wilcoxon signed ranks test demonstrated a significant decrease at week 5 (p = 0.03). Conclusions: This suggests that high-frequency rTMS may increase cortical excitability in adolescents with treatment-resistant MDD.
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