期刊
JOURNAL OF CHEMOTHERAPY
卷 20, 期 5, 页码 609-614出版社
TAYLOR & FRANCIS LTD
DOI: 10.1179/joc.2008.20.5.609
关键词
Clarithromycin; bacterial load; malondialdehyde; myeloperoxidase; nitric oxide; Klebsiella pneumoniae B5055; macrophages
资金
- Indian Council of Medical Research (ICMR) New Delhi, India
Acute lung injuries due to acute lung infections remain the major cause of mortality. Thus antibiotics with immunomodulatory and anti-inflammatory activities regardless of their antibacterial properties, will help to overcome acute lung infection-induced injuries. The macrolide antibiotics have been shown to posses these properties. Clarithromycin has been shown to possess anti-inflammatory properties in chronic inflammatory conditions. So we evaluated the anti-inflammatory effect of clarithromycin treatment in Klebsiella pneumoniae B5055-induced acute lung infection in mice. The clarithromycin treatment significantly (p<0.05) decreased the bacterial load in the lungs of K. pneumoniae B5055-infected mice and significantly (p<0.05) increased macrophage activity. The clarithromycin treatment also significantly (p<0.05) decreased the neutrophil infiltration into the lungs and decreased myeloperoxidase (MPO) activity. Clarithromycin significantly (p<0.05) decreased malondialdehyde (MDA) and nitric oxide (NO) production and thus decreased acute lung injury occurring during acute lung infection.
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