期刊
JOURNAL OF CHEMICAL THEORY AND COMPUTATION
卷 8, 期 11, 页码 3998-4003出版社
AMER CHEMICAL SOC
DOI: 10.1021/ct300392f
关键词
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资金
- US-NIH [GM084149]
- HKBU Phys. Dept.
- HKBU-FRG
We apply concepts of covariant and contravariant vector space in differential geometry and general relativity to derive new, general, exact. relations between potential of mean force and free energy profile. These relations are immensely, practical in free energy simulations because a full Jacobian transformation (which is usually unknown) is not required; rather, only knowledge of the (constraint) coordinate of interest is needed. We reveal that in addition to the Jacobian determinant, the Jacobian Scale factor and Leibnizian contributions must also be considered; as well as a Fixman term with correct mass dependence. Our newly derived relations are verified with new nontrivial benchmark numerical examples for which exact results can be computed and compared with relations available in the literature that turn out to exhibit significant deviations from the exact values.
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