期刊
ACTA BIOMATERIALIA
卷 20, 期 -, 页码 82-93出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.actbio.2015.03.029
关键词
Poly(beta-amino ester)s; SiRNA; Polyplexes; Non viral systems; Nanoparticles
资金
- Ministerio de Ciencia y Competividad of Spain [SAF2012-39947-C02-0]
Here we present an extended family of pBAEs that incorporate terminal oligopeptide moieties synthesized from both positive and negative amino acids. Polymer formulations of mixtures of negative and positive oligopeptide-modified pBAEs are capable of condensing siRNA into discrete nanoparticles. We have demonstrated that efficient delivery of nucleic acids in a cell-type dependent manner can be achieved by careful control of the pBAE formulation. In addition, our approach of adding differently charged oligopeptides to the termini of poly(beta-amino ester)s is of great interest for the design of tailored complexes having specific features, such as tuneable zeta potential. We anticipate that this surface charge tunability may be a powerful strategy to control unwanted electrostatic interactions, while preserving high silencing efficiency and reduced toxicity. (C) 2015 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
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