期刊
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
卷 41, 期 1, 页码 47-58出版社
WILEY
DOI: 10.1111/nan.12197
关键词
propagation; tauopathy; transmission
资金
- UK Medical Research Council [U105184291]
- Swiss National Science Foundation [31003A_152846]
- Desiree and Niels Yde Foundation
- Forschungsfonds der Universitat Basel
- Fondation Floshield Neuchatel
- Swiss Nanoscience Institute - Argovia
- Fanuc Robotics Schweiz
- Medical Research Council [MC_U105184291] Funding Source: researchfish
- Swiss National Science Foundation (SNF) [31003A_152846] Funding Source: Swiss National Science Foundation (SNF)
- MRC [MC_U105184291] Funding Source: UKRI
Filaments made of hyperphosphorylated tau protein are encountered in a number of neurodegenerative diseases referred to as 'tauopathies'. In the most prevalent tauopathy, Alzheimer's disease, tau pathology progresses in a stereotypical manner with the first lesions appearing in the locus coeruleus and the entorhinal cortex from where they appear to spread to the hippocampus and neocortex. Propagation of tau pathology is also characteristic of argyrophilic grain disease, where the tau lesions appear to spread throughout distinct regions of the limbic system. These findings strongly implicate neurone-to-neurone propagation of tau aggregates. Isoform composition and morphology of tau filaments can differ between tauopathies suggesting the existence of conformationally diverse tau strains. Altogether, this points to prion-like mechanisms in the pathogenesis of tauopathies.
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