期刊
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
卷 41, 期 1, 页码 24-46出版社
WILEY
DOI: 10.1111/nan.12213
关键词
FTDP-17 MAPT; tau aggregation; neurofibrillary tangle; Pick body; tau; [F18]-T807
资金
- UK Medical Research Council [U105184291]
- [P30 AG010133]
- [R21 NS084156]
- [P50 AG016574]
- [R01 AG011378]
- Medical Research Council [MC_U105184291] Funding Source: researchfish
- MRC [MC_U105184291] Funding Source: UKRI
Hereditary frontotemporal dementia associated with mutations in the microtubule-associated protein tau gene (MAPT) is a protean disorder. Three neuropathologic subtypes can be recognized, based on the presence of inclusions made of tau isoforms with three and four repeats, predominantly three repeats and mostly four repeats. This is relevant for establishing a correlation between structural magnetic resonance imaging and positron emission tomography using tracers specific for aggregated tau. Longitudinal studies will be essential to determine the evolution of anatomical alterations from the asymptomatic stage to the various phases of disease following the onset of symptoms.
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