期刊
JOURNAL OF CHEMICAL PHYSICS
卷 141, 期 5, 页码 -出版社
AMER INST PHYSICS
DOI: 10.1063/1.4890655
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资金
- National Science Foundation [DMR-0812470, DMR-0755447]
- National Institute of General Medical Sciences of the National Institutes of Health [R15GM106326]
- Direct For Mathematical & Physical Scien
- Division Of Materials Research [0812470] Funding Source: National Science Foundation
- Office Of The Director
- EPSCoR [1004083] Funding Source: National Science Foundation
We investigate the combined effects of transmembrane proteins and the subjacent cytoskeleton on the dynamics of phase separation in multicomponent lipid bilayers using computer simulations of a particle-based implicit solvent model for lipid membranes with soft-core interactions. We find that microphase separation can be achieved by the protein confinement by the cytoskeleton. Our results have relevance to the finite size of lipid rafts in the plasma membrane of mammalian cells. (C) 2014 AIP Publishing LLC.
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