期刊
NEURON
卷 85, 期 2, 页码 289-295出版社
CELL PRESS
DOI: 10.1016/j.neuron.2014.12.037
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资金
- Medical Research Council (UK) [U117537087]
- Medical Research Council (Sweden)
- KI-Fonder
- LKC School of Medicine NTU, Singapore
- European Union
- Medical Research Council [MC_U117537087] Funding Source: researchfish
- The Francis Crick Institute [10128] Funding Source: researchfish
- MRC [MC_U117537087] Funding Source: UKRI
The intrinsic neural networks of the gastrointestinal tract are derived from dedicated neural crest progenitors that colonize the gut during embryogenesis and give rise to enteric neurons and glia. Here, we study how an essential subpopulation of enteric glial cells (EGCs) residing within the intestinal mucosa is integrated into the dynamic microenvironment of the alimentary tract. We find that under normal conditions colonization of the lamina propria by glial cells commences during early postnatal stages but reaches steady-state levels after weaning. By employing genetic lineage tracing, we provide evidence that in adult mice the network of mucosal EGCs is continuously renewed by incoming glial cells originating in the plexi of the gut wall. Finally, we demonstrate that both the initial colonization and homeostasis of glial cells in the intestinal mucosa are regulated by the indigenous gut microbiota.
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