期刊
NEURON
卷 86, 期 3, 页码 617-631出版社
CELL PRESS
DOI: 10.1016/j.neuron.2015.03.021
关键词
-
资金
- Gatsby Charitable Foundation
- Crick Jacobs Center of the Salk Institute
- Salk Innovation Award
- National Institutes of Health [R01 EY021827, R01-HD063276, R01-HD057121, R01-HD059946, R01-EY021214, P51-OD011092]
- Brain Mapping by Integrated Neurotechnologies for Disease Studies (Brain/MINDS)
- Ministry of Education, Culture, Sports, Science, and Technology of Japan (MEXT)
- U.S. National Institutes of Health, NINDS
- NIMH
- G. Harlod and Leila Y. Mathers Charitable Foundation
- Leona M. and Harry B. Helmsley Charitable Trust [2012-PG-MED002]
- Poitras Center for Affective Disorders Research at McGovern Institute for Brain Research at MIT
- Stanley Center for Psychiatric Research at Broad Institute of MIT and Harvard
- Science Innovation Award from Brain Research Foundation
- Salk Innovation Grant
- Clayton Foundation
- National Institute of Aging
- National Institute of Neurological Disorders and Stokes
- NSF-IDBR
- NIDCD
- Leducq Foundation
- OHSU institutional funds
- NIH Director's New Innovator Award Program [1-DP2-OD006495-01]
- NARSAD Independent Investigator Grant
- NEI
- Howard Hughes Medical Institute
- Office of Naval Research
- NINDS, NIH
- National Institutes of Health (through NIMH) [5DP1-MH100706]
- National Institutes of Health (through NIDDK) [5R01-DK097768]
- National Science Foundation
- Keck, New York Stem Cell
- Damon Runyon Foundation
- Searle Scholars Foundation
- Merkin Foundation
- Vallee Foundation
- Bob Metcalfe
- San Bio Co. Ltd.
One of the great strengths of the mouse model is the wide array of genetic tools that have been developed. Striking examples include methods for directed modification of the genome, and for regulated expression or inactivation of genes. Within neuroscience, it is now routine to express reporter genes, neuronal activity indicators, and opsins in specific neuronal types in the mouse. However, there are considerable anatomical, physiological, cognitive, and behavioral differences between the mouse and the human that, in some areas of inquiry, limit the degree to which insights derived from the mouse can be applied to understanding human neurobiology. Several recent advances have now brought into reach the goal of applying these tools to understanding the primate brain. Here we describe these advances, consider their potential to advance our understanding of the human brain and brain disorders, discuss bioethical considerations, and describe what will be needed to move forward.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据