期刊
NEURON
卷 86, 期 5, 页码 1265-1276出版社
CELL PRESS
DOI: 10.1016/j.neuron.2015.05.012
关键词
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资金
- Research Council of Norway (FRIBIO) [197184]
- European Research Council [208132]
- Nanyang Technological University
- University of Warwick
- Funding Program for Next Generation World-Leading Researchers [LS023]
- [22115003]
- Grants-in-Aid for Scientific Research [13J01624] Funding Source: KAKEN
- European Research Council (ERC) [208132] Funding Source: European Research Council (ERC)
Temporally precise neuronal firing phase-locked to gamma oscillations is thought to mediate the dynamic interaction of neuronal populations, which is essential for information processing underlying higher-order functions such as learning and memory. However, the cellular mechanisms determining phase locking remain unclear. By devising a virus-mediated approach to perform multi-tetrode recording from genetically manipulated neurons, we demonstrated that synaptic plasticity dependent on the GluR1 subunit of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate) receptor mediates two dynamic changes in neuronal firing in the hippocampal CA1 area during novel experiences: the establishment of phase-locked firing to slow gamma oscillations and the rapid formation of the spatial firing pattern of place cells. The results suggest a series of events potentially underlying the acquisition of new spatial information: slow gamma oscillations, originating from the CA3 area, induce the two GluR1-dependent changes of CA1 neuronal firing, which in turn determine information flow in the hippo-campal-entorhinal system.
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