期刊
NEURON
卷 87, 期 2, 页码 297-309出版社
CELL PRESS
DOI: 10.1016/j.neuron.2015.05.041
关键词
-
资金
- NIH National Institute of Neurological Disorders and Stroke [R01NS058784, R21NS082894]
- CIRM [DR1-01480, RB5-07363]
- William Randolph Hearst Foundation
- American Brain Foundation
Stroke remains a leading cause of death and disability in the world. Over the past few decades our understanding of the pathophysiology of stroke has increased, but greater insight is required to advance the field of stroke recovery. Clinical treatments have improved in the acute time window, but long-term therapeutics remain limited. Complex neural circuits damaged by ischemia make restoration of function after stroke difficult. New therapeutic approaches, including cell transplantation or stimulation, focus on reestablishing these circuits through multiple mechanisms to improve circuit plasticity and remodeling. Other research targets intact networks to compensate for damaged regions. This review highlights several important mechanisms of stroke injury and describes emerging therapies aimed at improving clinical outcomes.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据