期刊
NEURON
卷 87, 期 3, 页码 657-670出版社
CELL PRESS
DOI: 10.1016/j.neuron.2015.06.037
关键词
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资金
- McDonnell Foundation Collaborative Activity award
- Hope Center for Neurological Disorders Pilot Award
- Intellectual and Developmental Disabilities Research Center at Washington University [NIH/NICHDP30 HD062171]
- Mallinckrodt Institute of Radiology Pilot Grant
- Child Neurology Foundation Scientific Research Award
- WU Child Health Research Center [K12-HD076224]
- McDonnell Center for Systems Neuroscience New Resource Proposal
- Dart NeuroScience LLC
- Texas Emerging Technology Fund
- [MH100872]
- [NS61144]
- [NS46424]
- [P30NS048056]
- [NS088590]
- [DGE-1143954]
- [MH091657]
Resting state functional MRI (fMRI) has enabled description of group-level functional brain organization at multiple spatial scales. However, cross-subject averaging may obscure patterns of brain organization specific to each individual. Here, we characterized the brain organization of a single individual repeatedly measured over more than a year. We report a reproducible and internally valid subject-specific areal-level parcellation that corresponds with subject-specific task activations. Highly convergent correlation network estimates can be derived from this parcellation if sufficient data are collected-considerably more than typically acquired. Notably, within-subject correlation variability across sessions exhibited a heterogeneous distribution across the cortex concentrated in visual and somato-motor regions, distinct from the pattern of intersubject variability. Further, although the individual's systems-level organization is broadly similar to the group, it demonstrates distinct topological features. These results provide a foundation for studies of individual differences in cortical organization and function, especially for special or rare individuals.
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