期刊
JOURNAL OF CHEMICAL PHYSICS
卷 137, 期 9, 页码 -出版社
AMER INST PHYSICS
DOI: 10.1063/1.4749257
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资金
- Ministry of Science and Informatics in Poland [UMO-2011/01/B/NZ1/01622]
- Department of Science and Technology at Ho Chi Minh city, Vietnam
A new method for determining the size of critical nucleus of fibril formation of polypeptide chains is proposed. Based on the hypothesis that the fibril grows by addition of a nascent peptide to the preformed template, the nucleus size N-c is defined as the number of forming template peptides above which the time to add a new monomer becomes independent of the template size. Using lattice models one can show that our method and the standard method which is based on calculation of the free energy, provide the same result for N-c (C) 2012 American Institute of Physics. [http://dx.doi.org/10.1063/1.4749257]
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