期刊
NEUROMUSCULAR DISORDERS
卷 25, 期 7, 页码 563-566出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.nmd.2015.03.001
关键词
Mitochondria; Fatigue; Depression; Anxiety; Sleep
资金
- Wellcome Trust [096919Z/11/Z, 074454/Z/04/Z]
- Medical Research Council [G0601943, G0800674]
- UK National Institute for Health Research Biomedical Research Centre for Ageing and Age-related Diseases award
- UK NHS Specialized Services and Newcastle upon Tyne Hospitals NHS Foundation Trust
- MRC [G0800470, G0601943, G0800674, MR/K000608/1, G0700718] Funding Source: UKRI
- Academy of Medical Sciences (AMS) [AMS-SGCL12-Payne] Funding Source: researchfish
- Medical Research Council [G0601943, G0800470, MR/K000608/1, G0700718, G0800674] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0510-10187, CL-2013-01-004] Funding Source: researchfish
Perceived fatigue is a prominent symptom in patients with mitochondrial disease but to date its prevalence, impact and aetiology are poorly understood. Our aim was to determine the prevalence and assess for comorbidities associated with clinically relevant fatigue in patients with mitochondrial disease. A cross-sectional postal survey of patients with mitochondrial disease was undertaken using a validated self-completion, patient-reported outcome measures (response rate: 60%; n = 132). The prevalence and perceived functional impact of experienced fatigue were assessed using the Fatigue Impact Scale. Other putative biological mechanisms were evaluated using the Hospital Anxiety Depression scale and Epworth sleepiness scale. Data were compared with those for healthy control subjects and patients with Myalgic Encephalopathy/Chronic Fatigue Syndrome matched for age and gender. Sixty-two per cent of patients with mitochondrial disease reported excessive symptomatic fatigue (Fatigue Impact Scale >= 40); whilst 32% reported severe, functionally limiting fatigue symptoms (Fatigue Impact Scale >= 80) comparable to perceived fatigue in patients with Myalgic Encephalopathy/Chronic Fatigue Syndrome. Fatigue is common and often severe in patients with mitochondrial disease irrespective of age, gender or genotype. Future evaluation of causal factors in mitochondrial disease-associated fatigue is warranted with the potential to guide future treatment modalities. (C) 2015 The Authors. Published by Elsevier B.V.
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