期刊
NEUROMODULATION
卷 19, 期 1, 页码 20-23出版社
WILEY-BLACKWELL
DOI: 10.1111/ner.12348
关键词
Basal ganglia; beta oscillations; deep brain stimulation; local field potentials; subthalamic nucleus
资金
- German Research Foundation (DFG) [KFO 247]
- Medical Research Council
- National Institute for Health Research Oxford Biomedical Research Centre
- MRC [MC_UU_12024/1, G0901503] Funding Source: UKRI
- Medical Research Council [G0901503, MC_UU_12024/1] Funding Source: researchfish
Objectives: Recent studies suggest that oscillatory beta activity could be used as a state biomarker in patients with Parkinson's disease for subthalamic closed-loop stimulation with the intention of improving clinical benefit. Here we investigate the feasibility of subthalamic recordings via a novel chronically implanted pulse generator. Methods: Subthalamic local field potential recordings were obtained from eight patients before and during deep brain stimulation (DBS). All data were analyzed in the frequency domain using Fourier transform-based methods and compared between ON and OFF stimulation conditions. Results: Distinct peaks of oscillatory beta band activity were found in 12 of 15 electrodes. DBS induced a significant frequency specific suppression of oscillatory beta activity (p = 0.002). Conclusion: The results of the study suggest that oscillatory beta band synchronization and its modulation by DBS is recordable with a system suitable for chronic implantation and may serve as a biomarker for subthalamic closed-loop stimulation in patients with Parkinson's disease.
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