4.7 Article

Cognitive activity relates to cognitive performance but not to Alzheimer disease biomarkers

期刊

NEUROLOGY
卷 85, 期 1, 页码 48-55

出版社

LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1212/WNL.0000000000001704

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资金

  1. National Institute on Aging [P01 AG036694, R01 AG034556, R01 AG037497, K01 AG040197]
  2. Alzheimer's Association Zenith Award
  3. National Institute of Biomedical Imaging and Bioengineering, NIH [P41EB015896]
  4. NIH Shared Instrumentation Grant Program
  5. High-End Instrumentation Grant Program [1S10RR023401, 1S10RR019307, 1S10RR023043, S10RR019254]

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Objective: We aimed to determine whether there was a relationship between lifestyle factors and Alzheimer disease biomarkers. Methods: In a cross-sectional study, we evaluated self-reported histories of recent and past cognitive activity, self-reported history of recent physical activity, and objective recent walking activity in 186 clinically normal individuals with mean age of 74 +/- 6 years. Using backward elimination general linear models, we tested the hypotheses that greater cognitive or physical activity would be associated with lower Pittsburgh compound B-PET retention, greater F-18-fluorodeoxyglucose-PET metabolism, and larger hippocampal volume, as well as better cognitive performance on neuropsychological testing. Results: Linear regression demonstrated that history of greater cognitive activity was correlated with greater estimated IQ and education, as well as better neuropsychological testing performance. Self-reported recent physical activity was related to objective exercise monitoring. However, contrary to hypotheses, we did not find evidence of an association of Pittsburgh compound B retention, F-18-fluorodeoxyglucose uptake, or hippocampal volume with past or current levels of cognitive activity, or with current physical activity. Conclusions: We conclude that a history of lifelong cognitive activity may support better cognitive performance by a mechanism that is independent of brain beta-amyloid burden, brain glucose metabolism, or hippocampal volume.

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