期刊
JOURNAL OF CHEMICAL INFORMATION AND MODELING
卷 53, 期 3, 页码 521-526出版社
AMER CHEMICAL SOC
DOI: 10.1021/ci400019t
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类别
资金
- National Institutes of Health [DA026434, DA034049, DA022413, MH054137, DA018151]
- CTSA [UL1TR000067]
Kappa-opioid (KOP) receptor agonists exhibit analgesic effects without activating reward pathways. In the search for nonaddictive opioid therapeutics and novel chemical tools to study physiological functions regulated by the KOP receptor, we screened in silico its recently released inactive crystal structure. A selective novel KOP receptor agonist emerged as a notable result and is proposed as a new chemotype for the study of the KOP receptor in the etiology of drug addiction, depression, and/or pain.
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