Amoxicillin Solubility and Supercritical Carbon Dioxide

During the past 20 years, an increase through measuring, correlating, and calculating solid solubilities especially pharmaceuticals in supercritical fluids for processes such as purification, extraction, and size reduction processes have been observed. In this direction, the solubility of amoxicillin with the International Union of Pure and Applied Chemistry (IUPAC) name of (2S,5R,6R)-6-{[(2R)-2-amino-2-(4-hydroxyphenyl)-acetyl]amino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0] heptane-2-carboxylic acid in the pressure and temperature ranges of 16 MPa to 40 MPa and 308.15 K to 338.15 K, respectively, has been measured. For this purpose, a simple gravimetric-based method was utilized to obtain the amoxicillin solubility in supercritical carbon dioxide. During the measurements it was found that the arnoxicillin solubility was in the range of 1.08.10(-5) and 7.23.10(-3) based on the mole fraction. Besides, due to a vast number of efforts have been performed on the solubility correlation by several researchers, four semiempirical density-based correlations including Mendez-Santiago and Teja (MST), Bartle et al., Chrastil, and Kumar and Johnston (K-J) models were used to correlate the measured solubility data. The obtained results revealed the capability of the used correlation through the solubility correlation with an acceptable level of accuracy.