期刊
JOURNAL OF CHEMICAL AND ENGINEERING DATA
卷 56, 期 12, 页码 4473-4479出版社
AMER CHEMICAL SOC
DOI: 10.1021/je2004319
关键词
-
资金
- S.U. Research Foundation [BAP: 10101016]
This study is the first report on the extraction of poorly soluble drug molecules such as nifedipine, niclosamide, and furosemide from the organic phase to the aqueous phase by water-soluble p-phosphonate calix[n]arene receptors via a liquid-liquid phase extraction process. These water-soluble calixarene derivatives were easily obtained from the reaction between their corresponding chloromethylated derivatives and trimethyl phosphite. From the liquid-liquid phase extraction studies, it was observed that the size of the p-phosphonate calix[n]arenes changed the extraction percentage of selected drug molecules.
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