期刊
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
卷 38, 期 10, 页码 1667-1681出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/0271678X18788769
关键词
Blood-brain barrier; endothelium; alternative; drug discovery; bio-printing; cell line; stem cells cell lines; microfluidic; drug development
资金
- National Institutes of Health/ National Institute on Drug Abuse [2R01-DA029121-01A1]
- ARDF
The development of realistic invitro blood-brain barrier (BBB) models that recapitulate the physiological parameters and molecular aspect of the neurovascular unit (NVU) is of fundamental importance not only in CNS drug discovery but also in translational research. Successful modeling of the NVU would provide an invaluable tool to aid in dissecting out the pathological factors, mechanism of action (and corresponding targets) prodromal to the onset of CNS disorders. The field of BBB invitro modeling has seen many radical changes in the last few years with the introduction on novel technologies and methods to improve over existing models and develop new ones. Therefore, the goal of this review is to provide the readers with updated technical and operational details concerning current BBB platforms with special focus on stem cell technology used to establish a functional BBB model invitro. Furthermore, we provide a detailed update on rapidly advancing 3D printing technologies used for engineering BBB models which use is now fast expanding among researchers.
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