期刊
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
卷 34, 期 7, 页码 1096-1103出版社
SAGE PUBLICATIONS INC
DOI: 10.1038/jcbfm.2014.82
关键词
5-HT; depression; molecular imaging; PET; receptor imaging; SPECT
资金
- Austrian Science Fund [P22981]
- Austrian Science Fund (FWF) [P22981] Funding Source: Austrian Science Fund (FWF)
- Austrian Science Fund (FWF) [P 22981] Funding Source: researchfish
The success of serotonin-selective reuptake inhibitors has lent support to the monoamine theory of major depressive disorder (MDD). This issue has been addressed in a number of molecular imaging studies by positron emission tomography or single-photon emission computed tomography of serotonin reuptake sites (5-HTT) in the brain of patients with MDD, with strikingly disparate conclusions. Our meta-analysis of the 18 such studies, totaling 364 MDD patients free from significant comorbidities or medication and 372 control subjects, revealed reductions in midbrain 5-HTT (Hedges' g = -0.49; 95% Cl: (-0.84, -0.14)) and amygdala (Hedges' g = -0.50; 95% Cl: (-0.78, -0.22)), which no individual study possessed sufficient power to detect. Only small effect sizes were found in other regions with high binding (thalamus: g = -0.24, striatum: g = -0.32, and brainstem g = -0.22), and no difference in the frontal or cingulate cortex. Age emerged as an important moderator of 5-HTT availability in MDD, with more severe reductions in striatal 5-HTT evident with greater age of the study populations (P<0.01). There was a strong relationship between severity of depression and 5-HTT reductions in the amygdala (P=0.01). Thus, molecular imaging findings indeed reveal widespread reductions of similar to 10% in 5-HTT availability in MDD, which may predict altered spatial-temporal dynamics of serotonergic neurotransmission.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据