期刊
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
卷 34, 期 7, 页码 1169-1179出版社
SAGE PUBLICATIONS INC
DOI: 10.1038/jcbfm.2014.66
关键词
APOE epsilon 4; beta-amyloid; FDG PET; florbetapir PET; metabolic connectivity; mild cognitive impairment
资金
- National Research Council Canada-Industrial Research Assistance Program (NRC-IRAP)
- Alzheimer's Disease Neuroimaging Initiative (ADNI) (National Institutes of Health) [U01 AG024904]
- National Institute on Aging
- National Institute of Biomedical Imaging and Bioengineering
- Canadian Institutes of Health Research
- NIH [P30 AG010129, K01 AG030514]
- Alzheimer's Association
- Alzheimer's Drug Discovery Foundation
- BioClinica
- Biogen Idec
- Bristol-Myers Squibb Company
- Eisai
- Elan Pharmaceuticals
- Eli Lilly and Company
- F. Hoffmann-La Roche
Positron emission tomography (PET) studies using [F-18]2-fluoro-2-deoxyglucose (FDG) have identified a well-defined pattern of glucose hypometabolism in Alzheimer's disease (AD). The assessment of the metabolic relationship among brain regions has the potential to provide unique information regarding the disease process. Previous studies of metabolic correlation patterns have demonstrated alterations in AD subjects relative to age-matched, healthy control subjects. The objective of this study was to examine the associations between beta-amyloid, apolipoprotein E epsilon 4 (APOE epsilon 4) genotype, and metabolic correlations patterns in subjects diagnosed with mild cognitive impairment (MCI). Mild cognitive impairment subjects from the Alzheimer's Disease Neuroimaging Initiative (ADNI) study were categorized into beta-amyloid-low and beta-amyloid-high groups, based on quantitative analysis of [F-18]florbetapir PET scans, and APOE epsilon 4 non-carriers and carriers based on genotyping. We generated voxel-wise metabolic correlation strength maps across the entire cerebral cortex for each group, and, subsequently, performed a seed-based analysis. We found that the APOE epsilon 4 genotype was closely related to regional glucose hypometabolism, while elevated, fibrillar beta-amyloid burden was associated with specific derangements of the metabolic correlation patterns.
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