期刊
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
卷 34, 期 3, 页码 369-375出版社
SAGE PUBLICATIONS INC
DOI: 10.1038/jcbfm.2013.227
关键词
brain injury; caspase-1; IL-1; inflammasome; spinal cord injury; stroke
资金
- NINDS NIH HHS [NS059836, R01 NS059836, NS042133, R01 NS042133] Funding Source: Medline
The inflammasome is an intracellular multiprotein complex involved in the activation of caspase-1 and the processing of the proinflammatory cytokines interleukin-1,6 (IL-1 beta) and IL-18. The inflammasome in the central nervous system (CNS) is involved in the generation of an innate immune inflammatory response through IL-1 cytokine release and in cell death through the process of pyroptosis. In this review, we consider the different types of inflammasomes (NLRP1, NLRP2, NLRP3, and AIM2) that have been described in CNS cells, namely neurons, astrocytes, and microglia. Importantly, we focus on the role of the inflammasome after brain and spinal cord injury and cover the potential activators of the inflammasome after CNS injury such as adenosine triphosphate and DNA, and the therapeutic potential of targeting the inflammasome to improve outcomes after CNS trauma.
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